I don't think i can live without my phone, 8 hours i spent time to finish my job on the computer. And then i use OQcode to take subway, and purchase food on the online market. Of course, i always buy clothes on the internet, especialy at the midnight, it's a very very terriable custom, this is a huge bad behavier for my eyes......you know everyday when i go home from my company by bicyle, i even can not see the traffic lights clearly........
I don't think i am lonely with this situation, definately you too! Right?
You may not realize it, but it is all around us, hurt our eyes everyday --that's blue light. Blue light is the most harmful part of visible light. The eyes cannot filter out blue light, but blue light can penetrate the eyes directly to the fundus and cause damage. Computers, TVs, mobile phones... all kinds of electronic devices not only bring convenience to our lives, but also allow us to be fully exposed to the blue light, and there is no escape.
Then i study a lot of knowledge about eyecare products, try to ease this press, and i realized that the nessary ingredients in our eyes are Lutein and Zeaxanthin, which are nonrenewable in the human body. And there are products of eyecare, which is include Lutein and Zeaxanthin, and extracted from Marigold flower. That's means i belive it's totally natural and safety.
Kingsci Biotech is a raw material supplier of Marigold flower extract, and KS exports these natural ingredients to all over the world. The powder and oil products support sample test and 3rd test and provide competitive price and service.
With the development and utilization of Chinese herbal medicines, more Chinese medicinal materials and foods have been found to contain quercetin, such as rutin, forsythia, onion, cranberry, and apples, which contain quercetin and its derivatives. Quercetin supplement is one of the more widely studied flavonoids, and its powerful antioxidant and anti-inflammatory activities have been fully proven, with strong biological activity and extensive pharmacological effects. Quercetin has a therapeutic effect on cardiovascular diseases, but due to its extremely low water solubility, poor oral absorption, and low bioavailability, the research and application of quercetin in new dosage forms for cardiovascular diseases has also attracted more and more attention.
Studies have found that quercetin can inhibit cardiac hypertrophy caused by abdominal aorta constriction and improve diastolic function. In primary cardiomyocytes, quercetin can significantly reduce the surface area and atrial natriuretic factor induced by angiotensin Ⅱ in cardiomyocyte hypertrophy At the same time, quercetin can increase the activity of proteasome GSK3. In spontaneously hypertensive rats, quercetin to lower blood pressure and significantly reduce the ratio of left ventricle to body weight. In vitro experiments have found that quercetin supplement can inhibit the incorporation of leucine into H9C2 cells in a concentration-dependent manner and reduce the surface area of mast cells, indicating that quercetin can effectively inhibit the hypertrophy of H9C2 cells induced by angiotensin II. In addition, inhibiting myocardial hypertrophy can effectively reduce the death rate of cardiovascular diseases. Compared with rats in the sham operation group, rats in the abdominal aortic coarctation group have an increased heart weight ratio. Hypertrophy is completely suppressed, and related malondialdehyde products are also significantly reduced. In the model group ERK1/2, the activities of p38 MAPK, Akt and GSK-3β increased significantly with the increase of pressure load. After treatment with quercetin, the activity of these proteins was inhibited, indicating that quercetin can inhibit stress-induced cardiac hypertrophy. It develops and can play a protective role by reducing the oxidative stress state and inhibiting the activities of ERK1/2, p38 MAPK, Akt and GSK-3β.
Diabetes is related to cardiovascular risk. Some scholars have explored the effect of quercetin on platelet function and carotid thrombosis induced by iron chloride in type 1 diabetes model mice. The study found that the diabetes model rats taking quercetin maintained a significantly higher blood flow rate than the control rats not taking quercetin. In addition, the quercetin treatment group can significantly reduce the high platelet aggregation caused by diabetes, indicating that quercetin can effectively inhibit the formation of blood clots in diabetes, and can be used as an antiplatelet drug in the treatment of diabetes. In addition, quercetin can inhibit platelet aggregation caused by collagen, adenosine diphosphate and arachidonic acid, and agonist-induced GPIIb/IIIa activation. Quercetin can also inhibit the extracellular secretion of platelet particles. Quercetin can completely inhibit PI3K and Src kinase, moderately inhibit Akt1/2, and slightly inhibit p38 and ERK1/2. The combined application of quercetin with adenosine diphosphate and thromboxane A inhibitors can effectively inhibit the spread of platelets. The anti-platelet aggregation effect of quercetin is also related to the inhibition of Fyn kinase activity and the tyrosine phosphorylation of Syk and PLCγ2.
Clinical trials have found that quercetin intake greater than 500 mg/d for more than 8 weeks can effectively reduce systolic and diastolic blood pressure. In animal experiments, some researchers have observed from rats with renal hypertension that quercetin can directly affect the aortic pressure of rats, and found that 5-10 mol/L quercetin can quickly relieve the hypertension caused by acetylcholine. The blood vessel pressure of rats indicates that quercetin can reduce blood pressure by reducing blood vessel elasticity. The antihypertensive effect of quercetin can also be observed in spontaneously hypertensive rats.
Some scholars have studied the effects of quercetin on the central hemodynamics and myocardial ischemia parameters of patients with stable coronary heart disease (CHD). According to 24-hour dynamic electrocardiogram monitoring, under the influence of quercetin supplement treatment, ventricular premature beats (PVC) The amount is significantly reduced, showing the cardioprotective properties of quercetin under CHD conditions. To study the effect of quercetin and metabolites on U46619-induced contraction, by preparing a part of porcine coronary arteries for isometric tension recording or measuring cGMP content, it is proved that quercetin can selectively regulate cGMP dependence in isolated porcine coronary arteries Relaxation and related tolerance, inhibit receptor-mediated contraction of pig isolated coronary arteries through an endothelium-dependent effect, which is beneficial for the treatment of patients with angina pectoris.
Quercetin supplement has a certain curative effect on cardiovascular diseases, but its low water solubility limits the bioavailability and affects the therapeutic effect of quercetin. Although the combination of quercetin and other drugs can improve the shortcomings of poor oral absorption, its oral bioavailability is still very low. In order to improve the bioavailability of quercetin and improve the efficacy of the drug, scholars at home and abroad have passed a large number of experiments It is prepared into different dosage forms, mainly nano preparations, liposomes, self-microemulsions, solid dispersions, micelles, inclusion compounds and other dosage forms. These dosage forms can not only improve the bioavailability of quercetin, but also quercetin. The clinical application of cortex has laid the foundation.
Single emulsion solvent evaporation technology was used to develop polylactide-glycolic acid copolymer (PLGA) polymer-based quercetin nanoparticles, and the in vitro evaluation showed that compared with pure quercetin, its diuretic activity in vivo better.
The prepared quercetin self-microemulsion preparation has stable quality and simple process, which provides a basis for the development of a new dosage form of quercetin in the cardiovascular system.
Some scholars introduced an innovative fluorescent-based monooleic acid-based cubosome dispersion, which is composed of dansyl and PEO-PPO-PEO block copolymer PF108 hydrophilic arm ends conjugated, this new type of fluorescent-labeled block copolymer mixture It can effectively stabilize the cubic preparation in the aqueous solution, and use it to encapsulate quercetin without destroying the shape and structure of quercetin.
Compared with pure quercetin, MPM is highly stable in aqueous media, and the solubility of quercetin is also significantly improved.
Quercetin supplement has a wide range of pharmacological activities, especially in cardiovascular aspects. It not only lowers blood pressure and blood lipids, but also has anti-thrombotic effects and inhibits myocardial hypertrophy. It has great clinical application prospects. However, the absorption of quercetin is still a problem that is still being solved. How to improve the absorption rate of quercetin requires further research and discussion; secondly, most of the research on quercetin focuses on cell and animal experiments, human and clinical experiments. The research evidence is not rich enough. It is hoped that there will be greater progress in the clinical application of quercetin in the future, and its potential for the treatment of cardiovascular diseases can be fully tapped.